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Merck
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AV53850

Sigma-Aldrich

Anti-ZC3H14 antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-FLJ11806, Anti-MGC26892, Anti-NY-REN-37, Anti-UKp68, Anti-Zinc finger CCCH-type containing 14

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

35 kDa

物種活性

human

濃度

0.5 mg - 1 mg/mL

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... ZC3H14(79882)

免疫原

Synthetic peptide directed towards the N terminal region of human ZC3H14

應用

Anti-ZC3H14 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

ZC3H14 gene encodes a ubiquitously expressed evolutionarily conserved Cys(3)His zinc finger protein that belongs to poly(A)-binding protein family. The encoded protein plays an evolutionarily conserved role in regulating the poly(A) tail length in neurons.Poly(A)-binding proteins also impacts the gene expression by controlling mRNA stability, nuclear export, and translation.Mutation in ZC3H14 gene leads to brain disorder occur due to disrupted normal development and impairs neural function in humans and drosophila.

序列

Synthetic peptide located within the following region: KFPSPPLPIFLPPEPVDLGSITSSSCSLNELDNISHLLRKISADINEIKG

外觀

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Seth M Kelly et al.
RNA (New York, N.Y.), 20(5), 681-688 (2014-03-29)
The ZC3H14 gene, which encodes a ubiquitously expressed, evolutionarily conserved, nuclear, zinc finger polyadenosine RNA-binding protein, was recently linked to autosomal recessive, nonsyndromic intellectual disability. Although studies have been carried out to examine the function of putative orthologs of ZC3H14
Sara W Leung et al.
Gene, 439(1-2), 71-78 (2009-03-24)
The human ZC3H14 gene encodes an evolutionarily conserved Cys(3)His zinc finger protein that binds specifically to polyadenosine RNA and is thus postulated to modulate post-transcriptional gene expression. Expressed sequence tag (EST) data predicts multiple splice variants of both human and
Changhui Pak et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12390-12395 (2011-07-08)
Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervous system, and we

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