A9486

AG-09/1

≥98% (HPLC)

• 同義詞: 2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-(4-nitrophenyl)-acetamide
• 經驗公式（希爾表示法）: C₁₆H₁₄N₄O₄S
• CAS號碼: 356776-32-4
• 分子量：: 358.37
• MDL號碼: MFCD02321063
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329771051
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow to brown
• 溶解度: DMSO: ≥30 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: COc1ccc2[nH]c(SCC(=O)Nc3ccc(cc3)[N+]([O-])=O)nc2c1
• InChI: 1S/C16H14N4O4S/c1-24-12-6-7-13-14(8-12)19-16(18-13)25-9-15(21)17-10-2-4-11(5-3-10)20(22)23/h2-8H,9H2,1H3,(H,17,21)(H,18,19)
• InChI 密鑰: LYQDSNOFTIZWAX-UHFFFAOYSA-N

描述

生化／生理作用

AG-09/1 is a selective formyl peptide receptor 1 (FPR1) agonist; it activates chemotaxis in human neutrophils. Formyl peptide recetors (FPRs) are GPCRs mainly expressed in phagocytic leukocytes but with lower expression in many other cell types. Formyl peptides, act as Alarmins and are released from bacteria and damaged mitochondria, serving as chemoattractants for phagocyte recruitment to sites of inflammation, resulting in immune response. Because the endogenous ligands for FPRs are peptides and arachidonic acid metabolites, there are few small molecule tools for these receptors. A recent HTS of commercially available libraries yielded several FPR-1 selective agonists, of which AG-091 was the most potent. AG-091 induced intracellular calcium flux in FPR-1- but not FPR-2-expressing cells. It also caused chemotaxis and intracellular calcium flux in human leukocytes. AG-091 is a valuable tool for studying FPR1 function in immune and other disease states.

安全資訊

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H318
• 防範說明: P280 - P305 + P351 + P338
• 危險分類: Eye Dam. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable