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Merck
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文件

A9361

Sigma-Aldrich

蒿甲醚

≥98% (HPLC)

同義詞:

SM-224, 二氢青蒿素甲醚, 甲基还原青蒿素

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About This Item

經驗公式（希爾表示法）:
C16H26O5
CAS號碼:
71963-77-4
分子量：:
298.37
MDL號碼:
MFCD00866205
分類程式碼代碼:
51101908
PubChem物質ID:
329771050
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +155 to +175°, c = 0.5 in methanol

顏色

off-white to light brown

溶解度

DMSO: ≥20 mg/mL

起源

Novartis

儲存溫度

room temp

SMILES 字串

CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3

InChI

1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

InChI 密鑰

SXYIRMFQILZOAM-HVNFFKDJSA-N

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一般說明

青蒿素 (ART) 是一种存在于传统中草药青蒿中的天然化合物。

應用

蒿甲醚已被用于：
  • 作为抗血吸虫化合物测试其对幼虫期曼氏血吸虫的作用
  • 提高小鼠胚胎成纤维细胞 (MEF) 和人骨肉瘤HT1080 细胞对半胱氨酸饥饿 (STV) 引起的铁死亡的敏感性
  • 刺激胰岛及其对α到β分化转移的作用

生化／生理作用

蒿甲醚是青蒿素的一种甲醚衍生物。它可用于治疗疟疾寄生虫恶性疟原虫的多重耐药菌株，并显示出治疗血吸虫病的潜力。
青蒿素含有具备高反应活性的内过氧化合物桥，这种桥结构是其治疗潜力的核心。内过氧化合物键与疟原虫红细胞中的铁反应。 这导致产生直接靶向疟原虫的活性氧（ROS）。 青蒿素还可调节肿瘤细胞中的铁死亡。α蒿甲醚可减少细胞转录因子Arx 的表达。初生胰岛的长期暴露还会导致难以鉴定内分泌细胞类型及其功能。

特點和優勢

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

象形圖

FlameExclamation mark
GHS02,GHS07

訊號詞

Danger

危險聲明

H242,H302

危險分類

Acute Tox. 4 Oral - Org. Perox. D

儲存類別代碼

5.2 - Organic peroxides and self-reacting hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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S H Xiao et al.
Parasitology today (Personal ed.), 16(3), 122-126 (2000-02-26)
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J Utzinger et al.
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Human schistosomiasis, a chronic and debilitating parasitic disease of the tropics, is ranked second after malaria in terms of public health importance. At present, there is no vaccine available, and chemotherapy is the cornerstone of schistosomiasis control. Praziquantel is the
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PLoS neglected tropical diseases, 13(1), e0006590-e0006590 (2019-01-29)
The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a major threat. Even though PZQ is potent in killing adult worms, its activity against
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