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Merck
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重要文件

A6351

Sigma-Aldrich

A-315456

>98% (HPLC), solid

同義詞:

N-[3-(cyclohexylidene(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide

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About This Item

經驗公式(希爾表示法):
C18H23N3O2S
分子量::
345.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

>98% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: soluble 24 mg/mL
H2O: insoluble

SMILES 字串

CCS(=O)(=O)Nc1cccc(c1)C(=C2/CCCCC2)\c3cnc[nH]3

InChI

1S/C18H23N3O2S/c1-2-24(22,23)21-16-10-6-9-15(11-16)18(17-12-19-13-20-17)14-7-4-3-5-8-14/h6,9-13,21H,2-5,7-8H2,1H3,(H,19,20)

InChI 密鑰

MTZVJHSZYMWIAG-UHFFFAOYSA-N

基因資訊

human ... ADRA1D(146)

應用

A-315456 is a potent and selective α1D-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the α(1D)-adrenoceptor subtype in normal and disease states.

生化/生理作用

Selective α1D-adrenoceptor antagonist.

特點和優勢

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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S A Buckner et al.
European journal of pharmacology, 433(1), 123-127 (2002-01-05)
In functional assays, A-315456, N-[3-(cyclohexylidene-(1H-imidazol-4-ylmethyl))phenyl]ethanesulfonamide, behaved as an alpha(1D)-adrenoceptor subtype selective antagonist (pA(2)=8.34) in the rat aorta. It was 83-fold less potent at the alpha(1B)-adrenoceptor subtype expressed in the rat spleen, and was inactive at the alpha(1A)-adrenoceptor subtype expressed in

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