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A5602

Sigma-Aldrich

AMD3100 八盐酸盐 水合物

≥97% (NMR), solid, CXCR4 antagonist

同義詞:

1,1′-[1,4-亚苯基双(亚甲基)]双-1,4,8,11-四氮杂 八盐酸盐, JM3100, SID791, 普乐沙福

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About This Item

經驗公式(希爾表示法):
C28H54N8 · 8HCl · xH2O
CAS號碼:
分子量::
794.47 (anhydrous basis)
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

product name

AMD3100 八盐酸盐 水合物, ≥97% (NMR), solid

品質等級

化驗

≥97% (NMR)

形狀

solid

儲存條件

desiccated

溶解度

H2O: ≥10 mg/mL, clear

起源

Sanofi Aventis

儲存溫度

−20°C

SMILES 字串

Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2

InChI

1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2

InChI 密鑰

GKFHDCZYJHUPEN-UHFFFAOYSA-N

應用

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。 AMD3100已被用于一项研究,以确定其对口腔鳞状细胞癌中CXCR4的阻断和对淋巴结转移的抑制。

生化/生理作用

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。

特點和優勢

该化合物是由 Sanofi Aventis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单,请点击这里

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Imadeldin Yahya et al.
Scientific reports, 10(1), 5049-5049 (2020-03-21)
The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial arch-derived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the
Kelli P A MacDonald et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3180-3189 (2014-03-04)
The majority of allogeneic stem cell transplants are currently undertaken using G-CSF mobilized peripheral blood stem cells. G-CSF has diverse biological effects on a broad range of cells and IL-10 is a key regulator of many of these effects. Using
Sapna Devi et al.
The Journal of experimental medicine, 210(11), 2321-2336 (2013-10-02)
Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagonist
Christine Feig et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20212-20217 (2013-11-28)
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not
Andreas Lundqvist et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 6241-6249 (2013-11-19)
Plerixafor (Mozobil) is a CXCR4 antagonist that rapidly mobilizes CD34(+) cells into circulation. Recently, plerixafor has been used as a single agent to mobilize peripheral blood stem cells for allogeneic hematopoietic cell transplantation. Although G-CSF mobilization is known to alter

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