全部照片(1)

重要文件

來源證明/COA

A5229

Agitoxin-1

Name: Agitoxin-1
Brand: SIGMA

recombinant, expressed in E. coli, ≥98% (HPLC), lyophilized powder

登入查看組織和合約定價

全部照片(1)

About This Item

MDL號碼:

MFCD07370216

分類程式碼代碼:

12352200

化驗

≥98% (HPLC)

形狀

lyophilized powder

分子量

4021 Da

溶解度

H₂O: soluble
aqueous buffer: soluble

儲存溫度

−20°C

Amino Acid Sequence

Gly-Val-Pro-Ile-Asn-Val-Lys-Cys-Thr-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Ile-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys

應用

Agitoxin-1 is a potent blocker of the Shakervoltage-gated K⁺ channels. Agitoxin has also been used to improve multi-dimensional NMR of proteins.

生化／生理作用

Toxin found in the venom of the scorpion Leiurus quinquestriatus hebraeus. Potent blocker of the Shakervoltage-gated K⁺ channels as well as the mammalian homologues of Shaker

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Fast multi-dimensional NMR of proteins.

Eriks Kupce et al.

Journal of biomolecular NMR, 25(4), 349-354 (2003-05-27)

Three-dimensional HNCO and HNCA subspectra from a small protein (agitoxin, 4 kDa, enriched in carbon-13 and nitrogen-15), have been obtained by direct frequency-domain excitation of selected carbon and nitrogen sites. This new technique applies an array of several simultaneous soft

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom.

M L Garcia et al.

Biochemistry, 33(22), 6834-6839 (1994-06-07)

Three new toxins from the venom of the scorpion Leiurus quinquestriatus var. hebraeus have been identified on the basis of their ability to block the Shaker K+ channel. These toxins have been purified using HPLC techniques and characterized as 38

Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release.

G Suarez-Kurtz et al.

The Journal of pharmacology and experimental therapeutics, 289(3), 1517-1522 (1999-05-21)

Potent and selective peptidyl blockers of the Shaker-type (Kv1) voltage-gated potassium channels were used to determine the role of these channels in regulating the spontaneous motility of smooth muscle preparations. Margatoxin (MgTX), kaliotoxin, and agitoxin-2 at 1 to 10 nM

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務