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A2010

Sigma-Aldrich

Nα-乙酰基-L-赖氨酸

≥98% (TLC), suitable for ligand binding assays

同義詞:

N2-acetyl-L-lysine

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About This Item

線性公式:
H2N(CH2)4CH(NHCOCH3)CO2H
CAS號碼:
分子量::
188.22
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

product name

Nα-乙酰基-L-赖氨酸,

化驗

≥98% (TLC)

形狀

powder

技術

ligand binding assay: suitable

顏色

colorless to white

mp

256-258 °C (dec.) (lit.)

儲存溫度

−20°C

SMILES 字串

CC(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C8H16N2O3/c1-6(11)10-7(8(12)13)4-2-3-5-9/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1

InChI 密鑰

VEYYWZRYIYDQJM-ZETCQYMHSA-N

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應用

Nα-乙酰基L-赖氨酸已作为赖氨酰氧化酶的底物,用于合成真正的α-氨基己二酸半醛 (AAS)-p-氨基苯甲酸 (ABA)。它可用于合成4,4′-亚甲基二苯基二异氰酸酯 (MDI) 的氨基酸加成物。

生化/生理作用

Nα-乙酰基-L-赖氨酸是蛋白质原型α氨基酸L-赖氨酸的一种生物学上可获得的N-末端封端形式。Nα-乙酰基-L-赖氨酸是用于研究和表征赖氨酰氧化酶的一种底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Yael Belo et al.
Biochimica et biophysica acta. General subjects, 1863(9), 1343-1350 (2019-06-07)
The signal transducer and activator of transcription 3 (STAT3) protein is activated by phosphorylation of a specific tyrosine residue (Tyr705) in response to various extracellular signals. STAT3 activity was also found to be regulated by acetylation of Lys685. However, the
Jing Bi et al.
Emerging microbes & infections, 7(1), 108-108 (2018-06-15)
The DosR regulon is believed to be a key factor in latency adaptation of Mycobacterium tuberculosis and is strongly induced by multiple stresses, including hypoxia. Previous studies have revealed reversible acetylation of the conserved core DNA-binding lysine residue 182 (K182)
Wenhui Ren et al.
Scientific reports, 7, 39986-39986 (2017-01-04)
As members of bromodomain and extra-terminal motif protein family, bromodomain-containing proteins regulate a wide range of biological processes including protein scaffolding, mitosis, cell cycle progression and transcriptional regulation. The function of these bromodomain proteins (Brds) in innate immune response has
Heinz Neumann et al.
Molecular cell, 36(1), 153-163 (2009-10-13)
Lysine acetylation of histones defines the epigenetic status of human embryonic stem cells and orchestrates DNA replication, chromosome condensation, transcription, telomeric silencing, and DNA repair. A detailed mechanistic explanation of these phenomena is impeded by the limited availability of homogeneously
Yoshihiro Nakamura et al.
The Journal of biological chemistry, 282(6), 4193-4201 (2006-12-07)
The BET (bromodomains and extra terminal domain) family proteins recognize acetylated chromatin through their bromodomain and act as transcriptional activators. One of the BET proteins, BRD2, associates with the transcription factor E2F, the mediator components CDK8 and TRAP220, and RNA

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