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Merck
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文件

A0956

Sigma-Aldrich

异佛手柑内酯

同義詞:

2-氧代-(2H)-呋喃并(2,3-H)-1-苯并吡喃, 2H-呋喃[2,3-H]-1-苯并吡喃-2-酮, NSC 404563, 异补骨脂素

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About This Item

經驗公式(希爾表示法):
C11H6O3
CAS號碼:
分子量::
186.16
Beilstein:
153970
MDL號碼:
分類程式碼代碼:
85151701
PubChem物質ID:
NACRES:
NA.25

形狀

powder

品質等級

儲存溫度

2-8°C

SMILES 字串

O=C1Oc2c(C=C1)ccc3occc23

InChI

1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H

InChI 密鑰

XDROKJSWHURZGO-UHFFFAOYSA-N

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應用

异补骨脂素是一种有角的呋喃香豆素,可用作可光活化的分子,与 DNA 和不饱和脂肪酸反应形成单加合物。异补骨脂素可作为潜在的光疗法进行研究,并了解其作用机制和对 RNA 和 DNA 合成的影响。

生化/生理作用

角呋喃香豆素具有多种光生物效应。在长波紫外线照射下,与双链 DNA 形成单加合物,并与不饱和脂肪酸反应。抑制 Ehrlich 腹水肿瘤细胞中的 DNA 和 RNA 合成,以及细胞复制。

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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Liang Feng et al.
Archives of pharmacal research, 33(2), 225-230 (2010-03-03)
Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components. The pharmacokinetics, tissue distribution and excretion of the two compounds were studied by liquid chromatography-tandem mass spectrometry after intravenous administration to Wistar
Yuan Gu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3137-3143 (2009-08-13)
A rapid, specific and sensitive ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) method has been established for simultaneous quantitation of psoralen and isopsoralen in rat plasma. Plasma samples were pretreated by direct protein precipitation with acetonitrile. Chromatographic separations were performed on
Md Ataur Rahman et al.
Molecular and cellular biochemistry, 369(1-2), 95-104 (2012-07-07)
Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for its antiproliferative activity in treatment of different skin diseases. To verify the activity of angelicin, we employed human SH-SY5Y neuroblastoma cells to investigate its cytotoxicity, although
Paola Barraja et al.
ChemMedChem, 6(7), 1238-1248 (2011-05-17)
Heteroanalogues of angelicin, pyrrolo[3,2-h]quinazolines, were synthesized with the aim of obtaining new potent photochemotherapeutic agents. Many derivatives caused a significant decrease in cell proliferation in several human tumor cell lines after irradiation with UVA light (GI(50) =15.2-0.2 μM). Their phototoxicity
Paola Barraja et al.
Bioorganic & medicinal chemistry, 18(13), 4830-4843 (2010-07-16)
In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline--bioisosters of the angular furocoumarin angelicin--were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity

文章

DNA 損傷和修復機制對維持 DNA 的完整性至關重要。細胞 DNA 的損害與突變、癌症的發展等有關。

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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