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About This Item
經驗公式（希爾表示法）:
C89H125N23O25S3
CAS號碼:
分子量：:
2013.28
MDL號碼:
分類程式碼代碼:
51102829
NACRES:
NA.85
暫時無法取得訂價和供貨情況
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品質等級
化驗
≥90.0%
形狀
powder
溶解度
0.1 M HCl: 10 mg/mL
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
作用方式
protein synthesis | interferes
儲存溫度
2-8°C
一般說明
Chemical structure: tetracycline
應用
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe[1]. It is used to stimulate sodium transport in cultured human colonic epithelia[2].
生化／生理作用
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity[1]. It enhances chloride secretion in airway epithelium.
其他說明
Keep container tightly closed in a dry and well-ventilated place.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
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Igor Oliynyk et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 118(12), 982-990 (2010-11-26)
The lantibiotic duramycin (Moli1901, Lancovutide) has been suggested as a drug of choice in the treatment for cystic fibrosis (CF). It has been proposed that duramycin may stimulate chloride secretion through Ca²(+) -activated Cl⁻ channels (CaCC). We investigated whether duramycin
M M Cloutier et al.
The American journal of physiology, 259(3 Pt 1), C450-C454 (1990-09-01)
The effect of duramycin, a polypeptide antibiotic, on Cl- transport in canine tracheal epithelium mounted in Ussing chambers was studied. Over a narrow concentration range, duramycin increased short-circuit current (Isc) and net Cl- secretion and had no effect on mannitol
Andrei Marconescu et al.
Biochimica et biophysica acta, 1778(10), 2217-2224 (2008-06-24)
The major anionic phospholipid, phosphatidylserine (PS), and the neutral phospholipid, phosphatidylethanolamine (PE), are largely confined to the inner leaflet of the plasma membrane bilayer in mammalian cells under normal conditions. This asymmetry is lost when cells undergo apoptosis, become activated
K Sundquist
Bone and mineral, 20(1), 17-29 (1993-01-01)
Proton transport in microsomal vesicles derived from medullary bone of laying hens was observed to be inhibited in a dose-dependent manner with fusidic acid, 7-chloro-4-nitrobenz-2-oxa-1,3-diatzole (NBD-Cl), duramycin and dicyclohexylcarbodiimide (DCCD). The IC50 values were 570 microM, 4.5 microM, 10 micrograms/ml
Soichiro Matsunaga et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8200-8207 (2009-05-13)
We visualized nanometer-scale phospholipid particle fusion by scanning tunneling microscopy (STM) on an alkanethiol-modified gold substrate, induced by duramycin, a tetracyclic antibiotic peptide with 19 amino residues. Ultrasonic homogenization generated a suspension mainly consisting of minimal lipid particles (MLP) from
文章
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
在細菌抗藥性和新興傳染性疾病的情況下，核糖體合成的抗菌肽是抗生素研究中一個很有前景的焦點。
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