83907

利福平

≥97.0% (HPLC)

• 同義詞: 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV, 利米定, 甲哌利福霉素
• 經驗公式（希爾表示法）: C₄₃H₅₈N₄O₁₂
• CAS號碼: 13292-46-1
• 分子量：: 822.94
• Beilstein: 5723476
• EC號碼: 236-312-0
• MDL號碼: MFCD00151389
• 分類程式碼代碼: 51101500
• PubChem物質ID: 57652978

屬性

• 化驗: ≥97.0% (HPLC)
• 形狀: powder
• 顏色: faintly red to very dark red
• 溶解度: chloroform: 0.25 g/5mL
• 抗生素活性譜: mycobacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N5CCN(C)CC5)c(O)c4c3C2=O
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI 密鑰: JQXXHWHPUNPDRT-WLSIYKJHSA-N

描述

一般說明

Chemical structure: macrolide

應用

Rifampicin is used as a selective cytochrome P4503A4 inducer. Studies have shown that rifampicin inhibits African Swine Fever Virus replication in tissue culture and inhibits the induction of tyrosine aminotransferase by cortisol in rat hepatoma cells grown in culture .

生化／生理作用

作用方式：通过与RNA聚合酶的β-亚基结合抑制RNA合成的起始。

抑制DNA和蛋白质组装成成熟的病毒颗粒。

其他說明

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Store under inert gas.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335,H362
• 防範說明: P260 - P263 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves