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Merck
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重要文件

42137

Sigma-Aldrich

Lactosylsphingosine

≥98.0% (TLC)

同義詞:

(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl 4-O-β-D-galactopyranosyl-β-D-glucopyranoside

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About This Item

經驗公式(希爾表示法):
C30H57NO12
CAS號碼:
分子量::
623.77
Beilstein:
5680460
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.85

化驗

≥98.0% (TLC)

形狀

powder

脂質類型

sphingolipids

儲存溫度

−20°C

SMILES 字串

OC1[C@@H](O)[C@H](OC[C@@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC)OC(CO)[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2

InChI

1S/C30H57NO12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(34)19(31)18-40-29-27(39)25(37)28(22(17-33)42-29)43-30-26(38)24(36)23(35)21(16-32)41-30/h14-15,19-30,32-39H,2-13,16-18,31H2,1H3/b15-14+/t19-,20+,21?,22?,23+,24-,25-,26?,27-,28?,29-,30+/m1/s1

InChI 密鑰

MQKSCOKUMZMISB-VOCCQAPRSA-N

生化/生理作用

Lactosylsphingosine is relevant for cancer, as lactosyl-reative antibodies occur in sera of cancer patients.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Kevin Mills et al.
Rapid communications in mass spectrometry : RCM, 19(12), 1739-1748 (2005-05-24)
Novel internal standards have been synthesised for the quantitative determination by tandem mass spectrometry (MS/MS) of the sphingolipids that accumulate in lysosomal storage diseases. The [d4]C16- and [d47]C24-isoforms of galactosylceramide (CMH), lactosylceramide (CDH), globotriaosylceramide (CTH), cerebroside sulphate, sphingomyelin and G(M1)-
Takehiro Nagatsuka et al.
ACS applied materials & interfaces, 5(10), 4173-4180 (2013-05-15)
We have detected biological toxins using localized surface plasmon resonance (LSPR) and synthetic glycosyl ceramides (β-lactoside, globosyl trisaccharide (Gb3), or GM1 pentasaccharide) attached to gold (Au) nanoparticles. The particle diameters ranged from 5-100 nm. The detection sensitivity for three toxins
Xavier Buton et al.
Biochemistry, 41(43), 13106-13115 (2002-10-23)
The transbilayer movement of glycosphingolipids has been characterized in Golgi, ER, plasma, and model membranes using spin-labeled and fluorescent analogues of the monohexosylsphingolipids glucosylceramide and galactosylceramide and of the dihexosylsphingolipid lactosylceramide. In large unilamellar lipid vesicles, monohexosylsphingolipids underwent a slow
Sumita Mishra et al.
Glycobiology, 24(6), 518-531 (2014-03-25)
Hypertrophy is central to several heart diseases; however, not much is known about the role of glycosphingolipids (GSLs) in this phenotype. Since GSLs have been accorded several physiological functions, we sought to determine whether these compounds affect cardiac hypertrophy. By
Margarita L Malakhova et al.
The Journal of biological chemistry, 280(28), 26312-26320 (2005-05-20)
Mammalian glycolipid transfer proteins (GLTPs) facilitate the selective transfer of glycolipids between lipid vesicles in vitro. Recent structural determinations of the apo- and glycolipid-liganded forms of human GLTP have provided the first insights into the molecular architecture of the protein

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