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Merck
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重要文件

40843

Sigma-Aldrich

1,2-双(2-氨基-5-氟苯氧基)乙烷-N,N,N′,N′-四乙酸四(乙酰氧基甲基)酯

≥97.0% (HPLC)

同義詞:

5,5′-Difluoro-BAPTA-AM

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About This Item

經驗公式(希爾表示法):
C34H38F2N2O18
CAS號碼:
分子量::
800.66
Beilstein:
8181644
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

≥97.0% (HPLC)

儲存溫度

−20°C

SMILES 字串

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(F)cc1OCCOc2cc(F)ccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O

InChI

1S/C34H38F2N2O18/c1-21(39)49-17-53-31(43)13-37(14-32(44)54-18-50-22(2)40)27-7-5-25(35)11-29(27)47-9-10-48-30-12-26(36)6-8-28(30)38(15-33(45)55-19-51-23(3)41)16-34(46)56-20-52-24(4)42/h5-8,11-12H,9-10,13-20H2,1-4H3

InChI 密鑰

ZXXWTKAFGAXGHZ-UHFFFAOYSA-N

應用

1,2-双(2-氨基-5-氟苯氧基)乙烷-N,N,N′,N′-四乙酸四(乙酰氧基甲基)酯(5,5′-二氟-BAPTA-AM,5FBAPTA-AM),钙螯合剂,可用于调节钙水平和细胞内流动,以研究钙稳态和细胞信号传导。

其他說明

19F-NMR 钙指示剂

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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G A Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(23), 7178-7182 (1983-12-01)
Symmetrically substituted difluoro derivatives of 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (nFBAPTA) show large 19F NMR chemical shifts on chelating divalent cations. The complexes of Ca2+ with 4FBAPTA and 5FBAPTA show fast and slow exchange behavior, respectively, and the chemical shift or the areas
E Marban et al.
Circulation research, 66(5), 1255-1267 (1990-05-01)
Calcium has been implicated as a mediator of cell injury in ischemia and reperfusion, but direct measurements of Ca2+ are required to refine this idea. We used nuclear magnetic resonance spectroscopy and the Ca2+ indicator 5F-BAPTA to measure [Ca2+]i in
J M Boeynaems et al.
European journal of pharmacology, 233(1), 13-20 (1993-03-16)
Our observation that loading of bovine aortic endothelial cells with quin 2 or 1,2-bis(O-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) enhances their release of prostacyclin (PGI2) has been studied in detail. The action of the acetoxymethyl ester (AM) of BAPTA (BAPTA-AM) was biphasic: at
H L Kirschenlohr et al.
The Biochemical journal, 293 ( Pt 2), 407-411 (1993-07-15)
A new n.m.r. indicator, 1,2-bis-(2-[1-(hydroxycarbony)ethyl- (hydroxycarbonylmethyl)]amino-5-fluorophenoxy)ethane (DiMe-5FBAPTA), with a higher affinity for calcium (apparent Kd 46 nM, pH 7.2, 30 degrees C) than the parent 5FBAPTA chelator (Kd 537 nM, pH 7.1, 30 degrees C) has been used to measure
Jiao Zhang et al.
Development, growth & differentiation, 53(5), 679-696 (2011-06-16)
During the early blastula period of zebrafish embryos, the outermost blastomeres begin to undergo a significant thinning in the apical/basolateral dimension to form the first distinct cellular domain of the embryo, the enveloping layer (EVL). During this shape transformation, only

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