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Merck
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Key Documents

363R-3

Sigma-Aldrich

PAX-8 (SP348) Rabbit Monoclonal Antibody

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit blood

品質等級

共軛

unconjugated

抗體表格

IgG fraction of tissue culture supernatant

抗體產品種類

primary antibodies

無性繁殖

SP348

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL (concentrate (363R-34-RUO) Research Use Only)
vial of 0.1 mL
(concentrate (363R-34))

vial of 0.5 mL (concentrate (363R-35))
vial of 1.0 mL (concentrate (363R-36))
vial of 1.0 mL (concentrate (363R-36-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (363R-37-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (363R-37))
vial of 25.0 mL (pre-dilute ready-to-use (363R-30))
vial of 25.0 mL (pre-dilute ready-to-use (363R-30-RUO))
vial of 7.0 mL (pre-dilute ready-to-use (363R-38))
vial of 7.0 mL (pre-dilute ready-to-use (363R-38-RUO) Research Use Only)

製造商/商標名

Cell Marque

技術

immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:10-1:20 (concentrated))

同型

IgG

控制

ovarian carcinoma, papillary carcinoma of thyroid, renal cell carcinoma, (Fallopian Tube)

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

一般說明

PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in neoplastic transformation of some epithelial cell types of these mature tissues.1 It can be useful for marking several types of carcinoma including, but not limited to, ovarian serous carcinoma, clear cell renal cell carcinoma and papillary thyroid carcinoma. Certain anti-PAX-8 antibodies may react with lymphocytes and their neoplasms, which has been attributed to cross-reactivity with PAX-5 due to sequence homology between PAX-8 and PAX-5, but clone SP348 does not exhibit reactivity in these cell types.

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2


分析證明 (COA)

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Lucas Moretti et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(2), 231-236 (2011-11-01)
Recently, reports using immunohistochemistry and a polyclonal antibody directed against the N-terminal region of PAX8 describe PAX8 expression in malignant lymphomas. As the N-terminal regions of PAX family members, including the B-cell transcription factor PAX5, have high sequence homology, we
Ayhan Ozcan et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 751-764 (2011-02-15)
PAX 8 is a transcription factor that is essential for embryonic development of the kidney, Müllerian organs, and thyroid. It may also have a role in tumor development in these organs. The diagnostic utility of PAX 8 has not been
Guo-Xia Tong et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(9), 1218-1227 (2009-06-16)
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable repertoire of tissue-specific markers for the diagnosis of human tumors. Together with PAX2, PAX8 is a
Daisuke Nonaka et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 192-200 (2007-12-18)
Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these
Daisuke Nonaka et al.
The American journal of surgical pathology, 32(10), 1566-1571 (2008-08-30)
The ovary is a common site of involvement for metastasis and the breast is one of the most common sources. Metastatic breast carcinoma can mimic a primary ovarian carcinoma. Pax8 is a crucial transcription factor for organogenesis of the thyroid

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