化驗
97%
mp
115-116 °C (lit.)
SMILES 字串
NC(=O)c1cccc(N)c1
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI 密鑰
GSCPDZHWVNUUFI-UHFFFAOYSA-N
基因資訊
mouse ... Parp1(11545)
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產品號碼
描述
訂價
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Shunichi Shimizu et al.
The international journal of biochemistry & cell biology, 68, 119-127 (2015-09-20)
Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca(2+)-permeable channel. In monocytes/macrophages, H2O2-induced TRPM2 activation causes cell death and/or production of chemokines that aggravate inflammatory diseases. However, relatively high concentrations of H2O2 are required for activation of TRPM2
Wen Ji Li et al.
The journal of sexual medicine, 9(5), 1319-1327 (2012-03-21)
Endothelial dysfunction-induced abnormalities of the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the corpus cavernosum are thought to be the main factors involved in the pathogenesis of diabetes-induced erectile dysfunction (ED). Recent studies have shown that the poly(adenosine
Li-qun Zhang et al.
Shock (Augusta, Ga.), 37(5), 492-500 (2012-01-24)
The overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is considered a final common effector in ischemia/reperfusion (I/R) injury. The aim of the current study was to examine the precise time course of the activation of PARP in peripheral leukocytes
Edina Bakondi et al.
Free radical biology & medicine, 50(1), 86-92 (2010-10-28)
Changes in protein turnover are among the dominant metabolic changes during aging. Of special importance is the maintenance of nuclear protein homeostasis to ensure a coordinated cellular metabolism. Therefore, in the nucleus a special PARP-1-mediated mechanism of proteasomal activation exists
Chunyan Wang et al.
Diabetes/metabolism research and reviews, 28(4), 329-337 (2012-01-10)
Mammalian excision repair cross-complementing 1 (ERCC1) and ERCC4 (a.k.a xeroderma pigmentosum complementation group F) are nucleotide excision repair enzymes, which excise the 5' end of damaged DNA. ERCC1 and ERCC4 have an interactive relationship with poly (adenosine diphosphate ribose) polymerase
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