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224M-1

Sigma-Aldrich

Beta-Catenin (14) Mouse Monoclonal Antibody

clone 14, unconjugated, Cell Marque™

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

14, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (224M-14)
vial of 0.5 mL concentrate (224M-15)
bottle of 1.0 mL predilute (224M-17)
vial of 1.0 mL concentrate (224M-16)
bottle of 7.0 mL predilute (224M-18)

製造商／商標名

Cell Marque™

濃度

1.0-5.0 μg/mL (predilute)
25-125 μg/mL (concentrate)

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同型

IgG1

控制

fibromatosis of breast

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

membranous, nuclear

相關類別

一般說明

Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.

品質


IVD
IVD
IVD
RUO

聯結

Beta-Catenin Positive Control Slides, Product No. 224S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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分析證明 (COA)

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C Li et al.
The American journal of pathology, 153(3), 709-714 (1998-09-15)
Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated beta-catenin protein level. A major function of APC is
B A Alman et al.
The American journal of pathology, 151(2), 329-334 (1997-08-01)
Sporadic aggressive fibromatosis (also called desmoid tumor) is a monoclonal proliferation of spindle (fibrocyte-like) cells that is locally invasive but does not metastasize. A similarity to abdominal fibromatoses (desmoids) in familial adenomatous polyposis and a cytogenetic study showing partial deletion
Ejaz Butt et al.
F1000Research, 8, 613-613 (2019-05-02)
Background: Ependymomas are glial tumors derived from differentiated ependymal cells. In contrast to other types of brain tumors, histological grading is not a good prognostic marker for these tumors. In order to determine genomic changes in an anaplastic ependymoma, we
Elizabeth Montgomery et al.
The American journal of surgical pathology, 26(10), 1296-1301 (2002-10-03)
Although separating gastrointestinal stromal tumor (GIST) from mesenteric fibromatosis and sclerosing mesenteritis is clinically important, this distinction sometimes poses problems for practicing pathologists. In the STI571 (Gleevec, Imatinib) era, the problem may be further compounded when protocol-driven staining for CD117
C Kuhnen et al.
Pathology, research and practice, 196(5), 299-304 (2000-06-02)
Apart from its role in cell-adhesion, beta-catenin is regarded as an oncoprotein, the cytoplasmic level of which is regulated by APC as a tumor suppressor protein. Changes of chromosome 5q, the region that includes the APC-gene, are known to be
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文章

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

免疫組織化學在胃腸道癌症中的應用

結腸直腸癌是男性和女性的第三大常見癌症。預計 2016 年會有 136,000 例結腸直腸癌病例。

相關內容

Antibodies as Raw Material

Trusted IVDR-ready supplier of high-quality Cell Marque™ antibodies for diagnostic pathology and IHC, ensuring reliability and expert support.

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