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文件

Y0001532

炔诺酮乙酸酯

European Pharmacopoeia (EP) Reference Standard

同義詞:

17α-乙炔基-17β-羟基-19-去甲-4-雄甾烯-3-酮 17-乙酸酯, 17α-乙炔基-19-去甲睾酮 17β-乙酸酯, 17-羟基-19-去甲-17α-孕甾-4-烯-20-炔基-3-酮 乙酸酯, 去甲基脱氢羟孕酮 17-乙酸酯

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About This Item

經驗公式(希爾表示法):
C22H28O3
CAS號碼:
分子量::
340.46
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

norethisterone

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1

InChI 密鑰

IMONTRJLAWHYGT-ZCPXKWAGSA-N

基因資訊

human ... PGR(5241)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Norethisterone acetate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Health hazardEnvironment

訊號詞

Danger

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).
Africander D J, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 143, 404-415 (2014)
F Pommier et al.
Journal of chromatography. A, 750(1-2), 75-81 (1996-10-25)
An analytical method for the determination of norethisterone acetate (NETA) in human plasma by capillary gas chromatography-mass-selective detection (GC-MS), with testosterone acetate as internal standard, was developed and validated. After addition of the internal standard, the compounds were extracted from
Bente Juel Riis et al.
American journal of obstetrics and gynecology, 187(4), 1101-1116 (2002-10-22)
This article is focused on the use of norethisterone acetate as progestogen in hormone replacement therapy. Emphasis is made on the fact that the primary reason for adding a progestogen to hormone replacement therapy is to protect the endometrium against
Norethisterone and norethisterone acetate.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 21, 441-460 (1979-12-01)
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone

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