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Merck
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文件

S1148

Sigma-Aldrich

SBFI-AM

≥80% purity

同義詞:

钠指示剂 SBFI-AM, 钠结合苯并呋喃间苯二甲酸酯-AM

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About This Item

經驗公式(希爾表示法):
C56H58N2O23
CAS號碼:
分子量::
1127.06
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.47

product name

SBFI-AM,

儲存溫度

−20°C

品質等級

SMILES 字串

COc1cc2cc(oc2cc1N3CCOCCOCCN(CCOCC3)c4cc5oc(cc5cc4OC)-c6ccc(cc6C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c7ccc(cc7C(=O)OCOC(C)=O)C(=O)OCOC(C)=O

InChI

1S/C56H58N2O23/c1-33(59)72-29-76-53(63)37-7-9-41(43(21-37)55(65)78-31-74-35(3)61)49-23-39-25-51(67-5)45(27-47(39)80-49)57-11-15-69-16-12-58(14-18-71-20-19-70-17-13-57)46-28-48-40(26-52(46)68-6)24-50(81-48)42-10-8-38(54(64)77-30-73-34(2)60)22-44(42)56(66)79-32-75-36(4)62/h7-10,21-28H,11-20,29-32H2,1-6H3

InChI 密鑰

MWUYLQGOGOLRQS-UHFFFAOYSA-N

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應用

细胞渗透性钠选择性荧光指示剂

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. The factors that induce these changes remain unknown. Conversely, functional recovery following
X Chen et al.
Biochemistry, 33(46), 13769-13774 (1994-11-22)
Although the predominance of plasmalogens in electrically-active membranes (e.g., sarcolemma) is well-known, identification of the molecular mechanisms through which the vinyl ether linkage facilitates electrophysiologic function has remained elusive. Herein we demonstrate that the kinetics of both carrier-mediated (i.e., valinomycin)
A Minta et al.
The Journal of biological chemistry, 264(32), 19449-19457 (1989-11-15)
Fluorescent indicators sensitive to cytosolic concentrations of free Na+ have been synthesized and characterized. They consist of a crown ether, 1,7-diaza-4,10,13-trioxacyclopentadecane, linked via its nitrogens to fluorophores bearing additional liganding centers. In the currently preferred dye, SBFI (short for sodium-binding
Sung-Kyun Ko et al.
Nature chemistry, 6(10), 885-892 (2014-09-23)
Anion transporters based on small molecules have received attention as therapeutic agents because of their potential to disrupt cellular ion homeostasis. However, a direct correlation between a change in cellular chloride anion concentration and cytotoxicity has not been established for

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