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等級
analytical standard
品質等級
化驗
>99% (TLC)
形狀
powder
技術
HPLC: suitable
gas chromatography (GC): suitable
顏色
white
應用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
形式
neat
SMILES 字串
Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1
InChI
1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
InChI 密鑰
FIKFLLIUPUVONI-UHFFFAOYSA-N
基因資訊
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269)
應用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化／生理作用
具有抗炎功能的支气管扩张药。通过其抗毒蕈碱作用，在接头前水平抑制黏液分泌并降低速激肽的释放。它还可以是 α 肾上腺素和 H1 组胺受体的拮抗剂
Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
J Cortijo et al.
European journal of pharmacology, 341(1), 79-86 (1998-03-07)
We have investigated the role of human bronchial cyclic nucleotide phosphodiesterases in the effects of fenspiride, a drug endowed with bronchodilator and anti-inflammatory properties. Functional studies on human isolated bronchi showed that fenspiride (10(-6)-3 x 10(-3) M, 30 min) induced
J C Féray et al.
Biochemical pharmacology, 54(2), 293-297 (1997-07-15)
Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophages, high fenspiride concentrations (1 mM) were
Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug.
Mattsson C and Hellstrom S
European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 254(9-10), 425-429 (1997)
F Quartulli et al.
European journal of pharmacology, 348(2-3), 297-304 (1998-07-04)
Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced intracellular Ca2+ increase and eicosanoid formation. Histamine and a histamine H1 receptor agonist elicited a rapid
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