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45674

Sigma-Aldrich

红霉素

tested according to Ph. Eur.

同義詞:

红霉素

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About This Item

經驗公式(希爾表示法):
C37H67NO13
CAS號碼:
分子量::
733.93
Beilstein:
75279
EC號碼:
MDL號碼:
分類程式碼代碼:
51282304
PubChem物質ID:
NACRES:
NA.76

agency

EPA 1694
USP/NF
tested according to Ph. Eur.

品質等級

形狀

solid

顏色

white to faint yellow

溶解度

H2O: soluble 2 mg/mL
acetone: freely soluble
acetonitrile: freely soluble
alcohol: soluble
amyl acetate: moderately soluble
chloroform: soluble
diethyl ether: soluble
ethyl acetate: freely soluble

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

應用

environmental

作用方式

protein synthesis | interferes

SMILES 字串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI 密鑰

ULGZDMOVFRHVEP-RWJQBGPGSA-N

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一般說明

Chemical structure: macrolide

應用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。

包裝

25g

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

準備報告

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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文章

蛋白质合成是一个复杂、多步骤过程,涉及到很多酶以及构象排列。但是,阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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