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104043

Sigma-Aldrich

N-苯基-1-萘胺

reagent grade, 98%

同義詞:

1-(N-苯氨基)萘, N-(1-萘基)苯胺, NPN

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About This Item

線性公式:
C10H7NHC6H5
CAS號碼:
分子量::
219.28
Beilstein:
2211174
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

等級

reagent grade

品質等級

化驗

98%

形狀

solid

bp

226 °C/15 mmHg (lit.)

mp

60-62 °C (lit.)

λmax

252 nm

SMILES 字串

N(c1ccccc1)c2cccc3ccccc23

InChI

1S/C16H13N/c1-2-9-14(10-3-1)17-16-12-6-8-13-7-4-5-11-15(13)16/h1-12,17H

InChI 密鑰

XQVWYOYUZDUNRW-UHFFFAOYSA-N

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應用

N-苯基-1-萘胺可用作荧光探针,用于测定表面活性剂的临界胶束浓度。N-苯基-1-萘胺被用于有机锂和有机镁试剂浓度的测定方法中。N-苯基-1-萘胺被用作疏水性探针,用于研究全细胞中膜脂质的相变

生化/生理作用

N-苯基-1-萘胺与细胞膜的疏水区域结合后,会发出荧光

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1B - STOT RE 2

標靶器官

Blood

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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G M Halliday et al.
Journal of immunological methods, 28(3-4), 381-390 (1979-01-01)
N-phenyl-1-naphthylamine (NPN) becomes fluorescent after binding to hydrophobic regions of cell membranes. Rat and mouse lymphoid cell suspensions stained with NPN showed changes in fluorescence emission 30 min after stimulation with mitogen or antigen, detected by microfluorimetry. Incubation of NPN-labelled
Peter Richter et al.
Antibiotics (Basel, Switzerland), 8(4) (2019-09-25)
Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine.
Bergbreiter DE and Pendergrass E.
The Journal of Organic Chemistry, 46(1), 219-220 (1981)
Daniel Pletzer et al.
PLoS pathogens, 14(6), e1007084-e1007084 (2018-06-22)
With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there are no therapies that adequately address this
Guillaume Sautrey et al.
Antimicrobial agents and chemotherapy, 58(8), 4420-4430 (2014-05-29)
The development of novel antimicrobial agents is urgently required to curb the widespread emergence of multidrug-resistant bacteria like colistin-resistant Pseudomonas aeruginosa. We previously synthesized a series of amphiphilic neamine derivatives active against bacterial membranes, among which 3',6-di-O-[(2"-naphthyl)propyl]neamine (3',6-di2NP), 3',6-di-O-[(2"-naphthyl)butyl]neamine (3',6-di2NB)

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