推薦產品
生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
liquid
不包含
preservative
物種活性
human, mouse, rat
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
同型
IgG
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
一般說明
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~79-85 kDa TORC2 protein.
Recognizes the ~79-85 kDa TORC2 protein in primary hepatocytes, HepG2, NIH3T3, Min6, and FAO cells.
TORCs (Transducers Of Regulated cAMP Response Element-Binding (CREB) protein) are members of a conserved family of co-activators that enhance CRE-dependent transcription by a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB. Studies suggest that TORC phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP.
This Anti-TORC2 (454-607) Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of TORC2 (454-607).
免疫原
Human
a recombinant protein consisting of amino acids 454-607 of mouse TORC2 fused to GST
應用
Immunoblotting (1:2000, see comments)
Immunoprecipitation (1:100, see comments)
警告
Toxicity: Standard Handling (A)
外觀
Undiluted serum.
重構
For long-term storage, aliquot and freeze (-20°C). In the case of storage at -20°C, avoid freeze/thaw cycles.
分析報告
Positive Control
Primary rat hepatocytes, HepG2, NIH3T3, Min6, and FAO cells
Primary rat hepatocytes, HepG2, NIH3T3, Min6, and FAO cells
其他說明
Screaton, R.A., et al. 2004. Cell119, 61.
This antibody has been used to detect endogenous TORC2 by immunoblotting. For immunoprecipitation, 4 µl antibody in a total volume of 400 µl has been tested. May also detect a protein at ~60 kDa, which may be a degradation product of TORC2. Antibody should be titrated for optimal results in individual systems.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
John Le Lay et al.
Cell metabolism, 10(1), 55-62 (2009-07-09)
The liver contributes to glucose homeostasis by promoting either storage or production of glucose, depending on the physiological state. The cAMP response element-binding protein (CREB) is a principal regulator of genes involved in coordinating the hepatic response to fasting, but
Haitao Wang et al.
Molecular endocrinology (Baltimore, Md.), 22(7), 1596-1605 (2008-05-10)
The transcriptional coactivator peroxisome-proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is induced in the liver in response to fasting and coordinates the activation of targets necessary for increasing energy production for gluconeogenesis and ketogenesis. After partial hepatectomy, the liver must restore its mass
Julie A Highland et al.
American journal of physiology. Cell physiology, 307(7), C611-C621 (2014-08-01)
Entrainment of the intrinsic suprachiasmatic nucleus (SCN) molecular clock to the light-dark cycle depends on photic-driven intracellular signal transduction responses of SCN neurons that converge on cAMP response element-binding protein (CREB)-mediated regulation of gene transcription. Characterization of the CREB coactivator
Pablo E Hollstein et al.
Cancer discovery, 9(11), 1606-1627 (2019-07-28)
Mutations in the LKB1 (also known as STK11) tumor suppressor are the third most frequent genetic alteration in non-small cell lung cancer (NSCLC). LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kinases ("AMPKRs"). The function
Jae Min Lim et al.
Molecular & cellular proteomics : MCP, 22(10), 100637-100637 (2023-08-31)
cAMP response element-binding protein (CREB) regulated transcriptional coactivator 2 (CRTC2) is a critical transcription factor that maintains glucose homeostasis by activating CREB. Energy homeostasis is maintained through multiple pathways; therefore, CRTC2 may interact with other transcription factors, particularly under metabolic
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