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MMMP3MAG-79K

Millipore

MILLIPLEX®小鼠MMP磁珠组套 - 免疫学多重检测试剂盒

MMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple MMP biomarkers in mouse cell culture samples.

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About This Item

分類程式碼代碼:
12161503
eCl@ss:
32161000
NACRES:
NA.84

品質等級

200

物種活性

mouse

製造商／商標名

Milliplex®

assay range

standard curve range: 12-50,000 pg/mL
(MMP-8)
standard curve range: 12-50,000 pg/mL
(proMMP-9)
standard curve range: 2-10,000 pg/mL
(MMP-3)
standard curve range: 49-200,000 pg/mL
(MMP-2)
standard curve range: 5-20,000 pg/mL
(MMP-12)

技術

multiplexing: suitable

檢測方法

fluorometric (Luminex xMAP)

運輸包裝

wet ice

一般說明

MMPs（基质金属蛋白酶）是负责细胞外基质(ECM)分解的锌蛋白酶家族，在正常的生理过程中起关键作用，例如胚胎发育和组织形态发生、组织和骨骼重塑、伤口愈合和血管生成。这些过程依赖于MMPs在细胞表面受体的裂解、凋亡配体的释放、细胞增殖和分化以及趋化因子活性调节中的作用。在结构上相似，MMP被合成并分泌为需要蛋白水解切割才能激活的无活性原酶。该过程可以由丝氨酸蛋白酶或其他MMP介导。MMP表达的增加是对多种刺激（包括粘附分子、生长因子、细胞因子和激素）的响应而发生的。MMP活性的调节主要由TIMP（金属蛋白酶的组织抑制剂）控制。因此，MMP/TIMP平衡的破坏可导致自身免疫性疾病、关节炎、心血管疾病以及肿瘤的生长和转移。

MILLIPLEX®小鼠MMP珠组套3，MMMP3MAG-79K是一种5重试剂盒，用于同时定量组织培养样品中的以下任何或所有分析物：MMP-2、MMP-3、MMP-8、proMMP-9和MMP-12。

组套类型：细胞因子/趋化因子

特異性

本组套中抗体与任何其他分析物之间的交叉反应性不可检出或可忽略不计。

應用

  • 分析物：MMP-2、MMP-3、MMP-8、proMMP-9、MMP-12
  • 建议样品类型：细胞/组织培养上清液或提取物
  • 研究类别：炎症&免疫学

特點和優勢

通过在此组套中选择可用的分析物来设计多重试剂盒。

儲存和穩定性

试剂盒组件的建议储存温度为2 - 8°C。

其他說明

灵敏度：单个分析物的灵敏度见方案

法律資訊

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

標靶器官

Respiratory Tract

儲存類別代碼

10 - Combustible liquids

分析證明 (COA)

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Delphine Le Guennec et al.
Cancers, 14(1) (2022-01-12)
Our goal was to evaluate the effect of spontaneous physical activity on tumour immunity during aging. Elderly (n = 10/group, 33 weeks) ovariectomized C57BL/6J mice fed a hyperlipidic diet were housed in standard (SE) or enriched (EE) environments. After 4
Taotao Lao et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(32), E4681-E4687 (2016-07-23)
Genetic variants in Hedgehog interacting protein (HHIP) have consistently been associated with the susceptibility to develop chronic obstructive pulmonary disease and pulmonary function levels, including the forced expiratory volume in 1 s (FEV1), in general population samples by genome-wide association
Lucy M Hinder et al.
Experimental neurology, 305, 33-43 (2018-03-20)
Diabetic peripheral neuropathy is the most common complication of diabetes and a source of considerable morbidity. Numerous molecular pathways are linked to neuropathic progression, but it is unclear whether these pathways are altered throughout the course of disease. Moreover, the
Phillipe D O'Brien et al.
Neurobiology of disease, 73, 348-355 (2014-12-03)
Given the lack of treatments for diabetic neuropathy (DN), a common diabetic complication, accurate disease models are necessary. Characterization of the leptin-deficient BTBR ob/ob mouse, a type 2 diabetes model, demonstrated that the mice develop robust diabetes coincident with severe
Ludovic Boytard et al.
Nature communications, 11(1), 4311-4311 (2020-08-29)
Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of

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