MABT165

Anti-p130cas/BCAR1 Antibody, clone 2C1.1

clone 2C1.1, from mouse

• 同義詞: Breast cancer anti-estrogen resistance protein 1, Cas scaffolding protein family member 1, Crk-associated substrate, p130Cas
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 2C1.1, monoclonal
• 物種活性: human
• 技術: western blot: suitable
• 同型: IgMκ
• NCBI登錄號: NP_055382
• UniProt登錄號: P56945
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... BCAR1(9564)

描述

一般說明

Breast cancer anti-estrogen resistance protein 1 (UniProt P56945; also known as Cas scaffolding protein family member 1, Crk-associated substrate, p130Cas) is encoded by the BCAR1 (also known as CAS, CAS1, CASS1, CRKAS) gene (Gene ID 9564) in human. p130Cas/BCAR1 is an adaptor protein that belongs to the CAS family of scaffold proteins, members of which also include Nedd9, HEF-1 (CAs-L), EFS, and CASS4. Structurally, p130Cas is composed of a Src-homology 3 (SH3) domain, an adjacent large substrate-binding domain containing 15 repetitions of the YxxP motif, a main site of tyrosine phosphorylation on the p130Cas/BCAR1 molecule that generates SH2-binding sites, a proline and serine rich region, and a highly conserved four-helix bundle (focal adhesion targeting [FAT] domain). p130Cas/BCAR1 plays an important role in transducing signaling originated from mechanical stimuli, extracellular matrix (ECM) adhesion, as well as growth factor stimulation cascades during normal development and diseases.

特異性

Expected to react with all eight spliced isoforms of human p130Cas reported by UniProt (P56945-1 through P56945-8).

免疫原

GST-tagged recombinant human p130cas/BCAR1 C-terminal fragment.

品質

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected p130cas/BCAR1 in 10 µg of A431 cell lysate.

標靶描述

~93 kDa observed. 93.14-97.88 kDa (isoforms 1-3 and isoforms 5-8) and 77.73 kDa (isoform 4) calculated. Fully phosphorylated target band migrates with an apparent molecular size of ~130 kDa

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2