MABS1814

Anti-GATA2 Antibody, clone 3C10.1

clone 3C10.1, from mouse

• 同義詞: Endothelial transcription factor GATA-2, GATA-binding protein 2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 3C10.1, monoclonal
• 物種活性: human
• 物種活性（以同源性預測）: mouse (based on 100% sequence homology)
• 包裝: antibody small pack of 25 μL
• 技術: western blot: suitable
• 同型: IgG2bκ
• NCBI登錄號: NP_001139133
• UniProt登錄號: P23769
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GATA2(2624)

描述

一般說明

Endothelial transcription factor GATA-2 (UniProt: P23769; also known as GATA-binding protein 2) is encoded by the GATA2 gene (Gene ID: 2624) in human. GATA2 is a zinc-finger transcriptional activator that regulates endothelin-1 gene expression in endothelial cells. It binds to the consensus sequence 5′-AGATAG-3′. GATA2 is expressed in embryonic brain and liver, endothelial cells, and in erythroid cells. GATA2 mutations appear to cause loss of function of the mutated allele leading to haploinsufficiency, which results in immunodeficiency characterized by significantly reduced or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells. However, it does not affect the T-cell number. This deficiency leads to increased susceptibility to mycobacterial, papillomavirus, and opportunistic fungal infections. Certain mutations in GATA2 are also linked to lymphedema that results in swelling of the extremities due to altered lymphatic flow.

特異性

Clone 3C10.1 specifically detects Endothelial transcription factor GATA-2 in human. It targets an epitope within 114 amino acids from the internal region.

免疫原

GST/His-tagged recombinant fragment corresponding to 114 amino acids from the internal region of human GATA2.

應用

Anti-GATA2 Antibody, clone 3C10.1, Cat. No. MABS1814, is a mouse monoclonal antibody that targets GATA2 and has been tested in Western Blotting.

品質

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected GATA2 in 10 µg of SH-SY5Y cell lysate.

標靶描述

~52 kDa observed; 50.50 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable