MABN838

Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1

clone 8D7.1, from mouse

• 同義詞: Retinal Dehydrogenase 1, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 8D7.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_000680
• UniProt登錄號: P00352
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ALDH1A1(216)

描述

一般說明

Retinal dehydrogenase 1 (EC 1.2.1.36; UniProt P00352; also known as Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, ALDH-E1, ALHDII, RALDH 1, RalDH1) is encoded by the ALDH1A1 (also known as ALDC, ALDH1, PUMB1) gene (Gene ID 216) in human. ALDH1A1, ALDH1A2, and ALDH1A3 constitute the ALDH1A subfamily of aldehyde dehydrogenases that catalyze the oxidation of all-trans retinal and 9-cis retinal to all-trans retinoic acid and 9-cis retinoic acid, respectively. In addition to its role in detoxifing 4-hydroxy-2-nonenal (4-HNE) in the lens and cornea, ALDH1A1 is also involved in many other biological processes, including stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids.

免疫原

Epitope: N-terminal

GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.

應用

Research Category
Neuroscience

Research Sub Category
Signaling Neuroscience

This Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Retinal Dehydrogenase 1/ALDH1A1.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of human cerebellum tissue lysate.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in human testis tissue.

品質

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of HepG2 cell lysate.

標靶描述

~55 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1k antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable