MABN652

Anti-Potassium Channel Kvβ2 Antibody

clone K17/70, from mouse

• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: K17/70, monoclonal
• 物種活性: rat, human
• 物種活性（以同源性預測）: mouse (based on 100% sequence homology)
• 技術: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_059000
• UniProt登錄號: P62483
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Kcnab2(16498)

描述

一般說明

Voltage-gated potassium channel subunit beta-2, also known as Potassium Channel Kv-Beta-2 or K(+) channel subunit beta-2 or Kv-beta-2, and encoded by the gene Kcnab2/Ckbeta2/Kcnb3, is part of the multi-subunit complex that comprises the potassium ion channel. Potassium Channel Kv-Beta-2 modulates the activity of the pore-forming alpha subunit of the potassium channel. Additionally, Potassium Channel Kv-Beta-2 forms heteromultimeric complexes with not only alpha subunits but also with kinase complexes such as PRKCZ and sequestosome complexes SQSTM1. Potassium Channel Kv-Beta-2 is localized to the plasma membrane and cytoplasm.

特異性

Other homologies: 100% homology to mouse KvB2.

This antibody does not cross react with Potassium Channel KvBeta1 or Potassium Channel Kv2.1 (Rhodes, K., et al. (1996). Journal of Neuro. 16(16):4846-4860).

免疫原

Recombinant protein corresponding to rat Potassium Channel Kvβ2.

應用

Detect Kv β2 using this mouse monoclonal antibody, Anti-Potassium Channel Kvβ2 Antibody validated for use in western blotting, IHC & ICC.

Immunocytochemistry Analysis: A representative lot detected Potassium Channel Kvβ2 in mammalian hippocampal neurons (Bu, C., et al. (2006). Neuron 52(5):803-816).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Potassium Channel Kvβ2 in human cerebellum, rat cerebellum, human cerebral cortex, and rat hindbrain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

品質

Evaluated by Western Blotting in SK-Mel-28 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Potassium Channel Kvβ2 in 10 µg of SK-Mel-28 cell lysate.

標靶描述

~39 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable