MABF2102

Anti-FcRH5 Antibody, clone F56

clone F56, from mouse

• 同義詞: Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, Immune receptor translocation-associated protein 2, IRTA2, CD307e
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: F56, monoclonal
• 物種活性: human
• 包裝: antibody small pack of 25 μL
• 技術: ELISA: suitable; flow cytometry: suitable; immunocytochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_112571.2
• UniProt登錄號: Q96RD9
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FCRL5(83416)

描述

一般說明

Fc receptor-like protein 5 (UniProt: Q96RD9; also known as FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, IRTA2, CD307e) is encoded by the FCRL5 (also known as FCRH5, IRTA2, UNQ503/PRO820) gene (Gene ID: 83416) in human. FcRH5 is a single-pass type I membrane protein that is expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. It is involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. It is shown to regulate BCR signaling and binds aggregated IgG and engages several of its Ig-domains to bind IgG. It is shown to be overexpressed in many lymphoma cell lines and on hairy cell leukemia cells. Serum levels of soluble FcRH5 are reported to be elevated in patients with several types of B cell tumors. FcRH5 is synthesized with a signal peptide (aa 1-15), which is cleaved off in the mature form that has a long extracellular domain (aa 16-851), a short transmembrane domain (aa 852-872), and a cytoplasmic tail (aa 873-977) that contains immunoreceptor tyrosine-based inhibitor motifs (ITIM). (Ref.: Franco, A., et al. (2013). J. Immunol. 190(11); 5739-46; Ise, T., et al. (2007). Leukemia 21(1); 169-174).

特異性

Clone F56 detects human Fc receptor-like protein 5. It targets an epitope with in the extracellular domain.

應用

Anti-FcRH5, clone F56, Cat. No. MABF2102, is a mouse monoclonal antibody that detects Fc receptor-like protein 5 and has been for use in ELISA, Flow Cytometry, Immunocytochemistry, and Western Blotting.

Immunocytochemistry Analysis: A representative lot detected FcRH5 in Immunocytochemistry applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

Western Blotting Analysis: A representative lot detected FcRH5 in Western Blotting applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

ELISA Analysis: A representative lot detected FcRH5 in ELISA applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

Flow Cytometry Analysis: A representative lot detected FcRH5 in Flow Cytometry applications (Ise, T., et. al. (2005). Clin Cancer Res. 11(1):87-96).

品質

Evaluated by Flow Cytometry in SU-DHL-5 cells.

Flow Cytometry Analysis: 1 µg of this antibody detected FcRH5 in one million SU-DHL-5 cells.

標靶描述

106.44 kDa calculated.

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.