MABE989

Anti-Homeodomain-only Protein Antibody, clone 15C1.1

clone 15C1.1, from mouse

• 同義詞: Lung cancer-associated Y protein, Homeodomain-only Protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.43
• 無性繁殖: 15C1.1, monoclonal
• application: WB
• 物種活性: mouse
• 技術: western blot: suitable

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 15C1.1, monoclonal
• 物種活性: mouse
• 物種活性（以同源性預測）: human (based on 100% sequence homology)
• 技術: western blot: suitable
• 同型: IgG2bκ
• NCBI登錄號: NP_001138931
• UniProt登錄號: Q9BPY8
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... HOPX(84525)

描述

一般說明

Homeodomain-only protein (UniProt Q9BPY8; also known as Lung cancer-associated Y protein, Not expressed in choriocarcinoma clone 1, Not expressed in choriocarcinoma protein 1, Odd homeobox 1 protein, Odd homeobox protein 1) is encoded by the HOPX (also known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO) gene (Gene ID 84525) in human. Human and mouse HOPX proteins share 92% identity, they contain homeobox-like domain but lack sequence motif required for DNA binding. HOPX is highly expressed in the developing heart, where its expression is dependent on the cardiac-restricted homeobox protein, Nkx2.5. HOPX physically interacts with serum responsive factor (SRF) and inhibits SRF-dependent transcription by inhibiting SRF binding to DNA and by recruiting histone deacetylase (HDAC) activity. HOPX is reported to play a critical role in the differentiation of various cells such as myoblasts, trophoblasts, keratinocytes, T cells, and lung alveolar cells. HOPX was initially reported as a differentiation marker and is expressed in various normal tissues, and HOPX expression is markedly suppressed in a subset of cancers.

特異性

Expected to react with spliced isoforms 1, 3, and 4. Reactivity toward isoform 2 has not been determined.

免疫原

GST-tagged recombinant protein corresponding to human Homeodomain-only Protein.

應用

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-Homeodomain-only Protein Antibody, clone 15C1.1 is validated for use in Western Blotting for the detection of Homeodomain-only Protein.

品質

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Homeodomain-only Protein in 10 µg of mouse lung tissue lysate.

標靶描述

~10 kDa observed. Uncharacterized band(s) may appear in some lysates.

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable