推薦產品
生物源
mouse
品質等級
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
7A7A9, monoclonal
物種活性
human
技術
immunohistochemistry: suitable
同型
IgG1
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... NCOR1(9611)
一般說明
Nuclear receptor corepressor 1 (N-CoR or N-CoR1), and encoded by the gene name NCOR, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. N-CoR1 is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. N-CoR1 is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17.
免疫原
Purified recombinant fragment of human N-CoR1 expressed in E. Coli
應用
Anti-N-CoR1, clone 7A7A9 Antibody detects level of N-CoR1 & has been published & validated for use in N-CoR1.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
品質
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected N-CoR1 in human cerebra and breast carcinoma tissues.
標靶描述
270 kDa calculated
外觀
Unpurified
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.
Yan-Yun Liu et al.
The Journal of biological chemistry, 290(12), 7402-7415 (2015-01-13)
Thyroid hormone and thyroid hormone receptor (TR) play an essential role in metabolic regulation. However, the role of TR in adipogenesis has not been established. We reported previously that TR sumoylation is essential for TR-mediated gene regulation and that mutation
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