MAB13446

Anti-TIMP-2 Antibody, clone 2TMP05

clone 2TMP05, Chemicon^®, from mouse

• 同義詞: Tissue Inhibitor of Metalloproteinase-2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 2TMP05, monoclonal
• 物種活性: human, mouse, bovine, guinea pig, rabbit, rat
• 製造商／商標名: Chemicon^®
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NM_003255.4
• UniProt登錄號: P16035
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TIMP2(7077)

描述

特異性

MAB13446 recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. CHEMICON MAB13446 may be used to evaluate the invasive nature of some tumor types and determine the tissue distribution of TIMPs in other tumors such as adenomas and also its normal tissue.

CELLULAR LOCALIZATION:

Cytoplasmic

免疫原

A synthetic peptide from the N-terminal region of human TIMP-2 protein.

應用

Detect TIMP-2 using this Anti-TIMP-2 Antibody, clone 2TMP05 validated for use in WB, IH(P).

Immunohistology (formalin/paraffin only): 2-4μg/ml 30 min at RT.

Western blotting: 1μg/ml for 2 hrs at RT.

(Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min. followed by cooling at RT for 20 min).

The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator.

Research Category
Cell Structure

Research Sub Category
MMPs & TIMPs

聯結

Replaces: MAB13448

外觀

Format: Purified

Purified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

儲存和穩定性

Antibody with sodium azide is stable for 12 months after date of receipt when stored at 2-8°C.

分析報告

Control
POSITIVE CONTROL:

Pancreatic or colon carcinoma

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable