FCABS350F

Milli-Mark^® Anti-TrkA-FITC Antibody

Milli-Mark^®, from rabbit

• 同義詞: Neurotrophic tyrosine kinase receptor type, Oncogene TRK, TRK1-transforming tyrosine kinase protein, high affinity nerve growth factor receptor, neurotrophic tyrosine kinase, receptor, type 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: FITC conjugate
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 製造商／商標名: Milli-Mark^®
• 技術: flow cytometry: suitable
• 同型: IgG
• NCBI登錄號: NP_067600
• UniProt登錄號: P35739
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified

描述

一般說明

TrkA is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.

特異性

Antibody recognizes TrkA protein.

Unconjugated version Cat.No.06-574 is predicted to react with Rat based on immunogen design. The unconjugated part number was also shown to react with Mouse.

免疫原

Bacterially expressed purified protein corresponding to the entire extracellular domain of rat TrkA receptor.

Epitope: Extracellular domain

應用

Detect TrkA using this Milli-Mark Anti-TrkA-FITC Antibody validated for use in FC.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

品質

Evaluated by flow cytometry using HeLa cells.

標靶描述

TrkA exists as two isoforms: 87 kDa and 88 kDa

外觀

Protein A purified

Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

儲存和穩定性

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

分析報告

Control
HeLa cells

法律資訊

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable