ABN34

Anti-PDE11A Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Dual 3′,5′-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, human
• 物種活性（以同源性預測）: rat (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 技術: immunohistochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_058649
• UniProt登錄號: Q9HCR9
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PDE11A(50940)

描述

一般說明

The PDE11A gene encodes for a dual-specificity Phosphodiesterase (PDE), which is expressed in the adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors. PDEs are known to catalyze cAMP and cGMP to 5’-AMP and 5’GMP, respectively and thereby regulate the intracellular concentration of these nucleotides. Loss-of-function mutation of the PDE11A gene is shown to increase cAMP signaling and cAMP-responsive element binding protein (CREB) phosphorylation, two conditions which are associated with adrenocortical hyperplasia, adenomas, and Cushing syndrome.

特異性

This antibody recognizes GAF domain of PDE11A.

免疫原

Epitope: GAF domain.

KLH-conjugated linear peptide corresponding to the GAF domain of human PDE11A.

應用

Detect PDE11A using this Anti-PDE11A Antibody validated for use in WB, IH.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected PDE11A in normal mouse midbrain tissue.

Research Category
Neuroscience

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

品質

Evaluated by Western Blot in human hippocampus tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE11A in 10 µg of human hippocampus tissue lysate.

標靶描述

~104 kDa observed. Uniprot states four isoforms at a molecular weight of ~105 kDa, ~78 kDa, ~66 kDa, and ~56 kDa This antibody can only recognize the ~105 kDa and the ~78 kDa isoforms.

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human hippocampus tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids