推薦產品
生物源
rabbit
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human, mouse, rat
技術
ChIP: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... PBRM1(55193)
一般說明
BRG1-associated factor 180 (BAF180) is a subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex, and is known to contain 6 bromo domains, 2 BAH domains, and a single HMG box DNA-binding domain. BAF180 has a critical and active role in the transcriptional activation and repression of specific genes via chromatin remodeling, including genes involved in the development of the heart, thus suggesting a role in mammalian development. Recent studies demonstrate BAF180 to suppress tumorigenesis through its ability to regulate both baseline and signal-dependent p21 transcription by its binding of the p21 promoter. Expression of BAF180 is reported in a wide range of tissues.
免疫原
GST-tagged recombinant protein corresponding to human BAF180.
應用
Anti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB.
Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in ChIP (Xia, W., et al. (2008).
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
品質
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.
標靶描述
~193 kDa observed
外觀
Protein G Purified
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
HEK293 cell lysate
HEK293 cell lysate
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Darmood Wei et al.
Genes, chromosomes & cancer, 59(8), 472-483 (2020-04-08)
Renal medullary carcinoma (RMC) is a rare, aggressive disease that predominantly afflicts individuals of African or Mediterranean descent with sickle cell trait. RMC comprises 1% of all renal cell carcinoma diagnoses with a median overall survival of 13 months. Patients are
Alena Shmakova et al.
Cells, 10(6) (2021-07-03)
PBRM1, a component of the chromatin remodeller SWI/SNF, is often deleted or mutated in human cancers, most prominently in renal cancers. Core components of the SWI/SNF complex have been shown to be important for the cellular response to hypoxia. Here
Christopher J Petell et al.
The Journal of biological chemistry, 299(8), 104996-104996 (2023-07-03)
A critical component of gene regulation is recognition of histones and their post-translational modifications by transcription-associated proteins or complexes. Although many histone-binding reader modules have been characterized, the bromo-adjacent homology (BAH) domain family of readers is still poorly characterized. A
Lili Liao et al.
Molecular oncology, 13(4), 811-828 (2018-12-27)
Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues. While BD2 has been found to bind acetylated histone H3 lysine 14 (H3K14ac), it is not
Cornelia Meisenberg et al.
Molecular cell, 73(2), 212-223 (2018-12-18)
Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a previously unknown role for cohesin. We
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