推薦產品
生物源
rabbit
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性（以同源性預測）
all
技術
ChIP: suitable
RIP: suitable
dot blot: suitable
運輸包裝
wet ice
目標翻譯後修改
unmodified
一般說明
N6-甲基腺苷（m6A），或腺苷N6位的甲基化，是RNA的一种转录后修饰。 由于分析方法的缺乏，人们对N6-甲基腺苷了解的很少，但新证据表明它是一种非常常见的碱基修饰和重要的生理调节因子。N6-甲基腺苷在整个大脑发育过程中都会显著增加，并会在终止密码子、microRNA结合位点和UTR附近富集，表明了其在基因表达调节中的基础性作用。N6-甲基腺苷在人和小鼠之间也高度保守。
免疫原
BSA偶联的N6-甲基腺苷。
應用
染色质免疫沉淀分析：A representative lot from an independent laboratory detected N6-methyladenosine in RNA containing N6-methyladenosine (Dominissini, D., et al. (2012).Nature.485(7397):201-206.; Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
(RNA) Immunoprecipitation Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in methylated RNA containing N6-methyladenosine (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.).
Dot Blot Analysis: A representative lot from an independent laboratory detected N6-methyladenosine in a panel of modified oligonucleotides (Meyer, K. D., et al. (2012).Cell.149(7):1635-1646.; Jia, G., et al. (2011).Nat Chem Biol. 7(12):885-887.).
研究子类别
染色质生物学
染色质生物学
研究类别
表观遗传学&核功能
表观遗传学&核功能
通过使用已验证用于斑点印迹、染色质IP（ChIP) & RNA结合蛋白IP（RIP）的抗-N6-甲基腺苷（m6A）抗体检测N6-甲基腺苷（m6A）。
品質
已通过斑点印迹在含有N6-甲基腺苷的低聚物中进行评估。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
斑点印迹分析： 1 µg/mL的该抗体可在含有N6-甲基腺苷的低聚物中检测到N6-甲基腺苷。
外觀
在含有0.05%叠氮化钠PBS的缓冲液中的纯化兔多抗。
形式：纯化
纯化的蛋白 A
儲存和穩定性
自发运之日起，在 2-8°C 条件下可稳定保存1年
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Andrea Orioli et al.
Genome research, 26(5), 624-635 (2016-03-05)
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-scale picture of Pol III regulation and the role played by its repressor MAF1 is lacking. Here, we describe genome-wide studies in human fibroblasts that
Xiaoling Liu et al.
Analytical chemistry, 90(9), 5546-5551 (2018-04-14)
N6-methyladenine (6mA) is a rediscovered DNA modification in eukaryotic genomes. To explore the distribution and functions of 6mA, it is of paramount option to use immunoprecipitation to select 6mA-containing DNA fragments for genome-wide sequencing. Presumably, most of the 6mA-free fragments
Hua Su et al.
BMC genomics, 21(1), 39-39 (2020-01-15)
Hypoxia mediated pulmonary hypertension (HPH) is a lethal disease and lacks effective therapy. CircRNAs play significant roles in physiological process. Recently, circRNAs are found to be m6A-modified. The abundance of circRNAs was influenced by m6A. Furthermore, the significance of m6A
Jérôme Lannes et al.
Scientific reports, 6, 31563-31563 (2016-08-20)
The GnRH neurohormone is the main activator of the pituitary gonadotropins, LH and FSH. Here we investigated the contribution of microRNAs in mediating GnRH activation. We first established that miR-125b targets several actors of Gαq/11 signalling pathway, without altering Gαs
Belinda Baquero-Perez et al.
eLife, 8 (2019-10-28)
N6-methyladenosine (m6A) is the most abundant internal RNA modification of cellular mRNAs. m6A is recognised by YTH domain-containing proteins, which selectively bind to m6A-decorated RNAs regulating their turnover and translation. Using an m6A-modified hairpin present in the Kaposi's sarcoma associated
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