ABE12

Anti-phospho CARM1 (Ser228) Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Protein arginine N-methyltransferase 4, coactivator-associated arginine methyltransferase 1, coactivator-associated arginine methyltransferase-1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, horse
• 物種活性（以同源性預測）: canine (based on 100% sequence homology), equine (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_954592
• UniProt登錄號: Q86X55
• 運輸包裝: wet ice
• 目標翻譯後修改: phosphorylation (pSer228)
• 基因資訊: human ... CARM1(10498)

描述

一般說明

CARM1 (coactivator-associated arginine methyltransferase 1) is an arginine N-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to arginine residues. This protein-arginine methyltransferase that works in conjunction with p300 and GRIP1 to enhance transcription. CARM1 methylation targets include histone H3 at Arg17 and p300 at Arg2142. CARM1 is recruited to promoters upon gene activation together with histone acetyltransferases from the p300 and p160 families. During monocyte inflammatory stimulation, CARM1 acts together with p300 as a coactivator for NF-kB. It is responsible for moving cells toward the inner cell mass in developing blastocysts. CARM1 also plays an important role in androgen receptors and may play a role in prostate cancer progression.

特異性

This antibody recognizes CARM1 phosphorylated at Ser228.

免疫原

Epitope: Phosphorylated Ser228

KLH-conjugated linear peptide corresponding to human CARM1 phosphorylated at Ser228.

應用

Anti-phospho CARM1 (Ser228) Antibody is a Rabbit Polyclonal Antibody for detection of phospho CARM1 (Ser228) also known as Protein arginine N-methyltransferase 4 & has been validated in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Histones

品質

Evaluated by Western Blot in EGF treated and untreated A431 cell lysates.

Western Blot Analysis: 2 µg/mL of this antibody detected CARM1 on 10 µg of EGF treated and untreated A431 cell lysates.

標靶描述

~63 kDa observed

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
EGF treated and untreated A431 cell lysates

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable