ABC849

Anti-ZIP-1 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Zinc transporter ZIP1, Solute carrier family 39 member 1, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1, ZIP-1, hZIP1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, mouse
• 技術: immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: Q9NY26
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SLC39A1(27173)

描述

一般說明

Zinc transporter ZIP1, also known as Solute carrier family 39 member 1 or Zinc-iron-regulated transporter-like or Zrt- and Irt-like protein 1 (ZIP-1 or hZIP1), and encoded by the gene name SLC39A1 or IRT1 or ZIP1 or ZIRTL, is responsible to the rapis uptake and accumulation of physiologically effective zinc in prostate cells. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to downregulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

特異性

This antibody is predicted to not cross-react with other ZIP family members.

免疫原

Epitope: N-terminus

KLH-conjugated synthetic peptide corresponding to the N-terminus of human ZIP-1.

應用

Anti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected ZIP-1 in human kidney tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in Mouse kidney tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ZIP-1 in Mouse kidney tissue lysate.

標靶描述

~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable