ABC517

Anti-PGAM5 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Serine/threonine-protein phosphatase PGAM5, mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rodent (based on 100% sequence homology), monkey (based on 100% sequence homology), hamster (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_001164014
• UniProt登錄號: Q96HS1
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PGAM5(192111)

描述

一般說明

PGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.

特異性

This antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.

免疫原

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.

應用

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.

品質

Evaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PGAM5 in 10 µg of HT-29 cell lysate.

標靶描述

~32/34 kDa observed.

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable