AB8230

Anti-Syndecan-1 Antibody

serum, from rabbit

• 同義詞: CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor ; ; receptor, syndecan 1, syndecan proteoglycan 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: serum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: mouse, human
• 技術: western blot: suitable
• NCBI登錄號: NM_001006946.1
• UniProt登錄號: P18827
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SDC1(6382)

描述

一般說明

Syndecan-1, also known as CD138, is a transmembrane (Type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization. Bearing properties of both heparan sulfate and chondroitin sulfate, Syndecan-1 functions as a cell surface proteoglycan membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.

特異性

Cat. No. AB8230 recognizes mouse Syndecan-1.

Predicted to cross react with human, based on 100% sequence homology.

Reactivity with other species has not been tested.

免疫原

His-tagged, full-length human recombinant Syndecan-1 protein.

應用

Anti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

品質

Evaluated on a representative lot by Western blot on mouse liver lysate using 1:1000 dilution of Anti-Syndecan-1.

標靶描述

The expected molecular weight of monomeric Syndecan-1 is ~32 kDa; however, the core protein often migrates as an SDS-stable dimer with an approximate M.W. of 77 kDa Additionally, a high M.W. form of the protein may often be seen between 500-1000 kDa, likely the mature form of Syndecan-1, with all of its heparan and chondroitin sulfate additions. In whole tissues, this mature form often binds tightly to ECM molecules and may require solublization by urea extraction for additional SDS-PAGE analysis (Wilsie, 2006). Triton X-100 or similar mild detergents are sufficient to release the immature precursor forms of Syndecan-1.

外觀

Rabbit serum containing 0.05% NaN3.

儲存和穩定性

Maintain at -20°C for up to 1 year from date of receipt.

分析報告

Control
Mouse liver lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1