AB3795

Anti-Cortactin Antibody, phospho-specific [Tyr466]

Chemicon^®, from rabbit

• 同義詞: Amplaxin, Oncogene EMS1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse
• 製造商／商標名: Chemicon^®
• 技術: western blot: suitable
• NCBI登錄號: NM_005231.2; NM_138565.1
• UniProt登錄號: Q14247
• 運輸包裝: wet ice
• 目標翻譯後修改: phosphorylation (pTyr466)
• 基因資訊: human ... CTTN(2017)

描述

一般說明

Cortactin is cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino-terminal tandem repeats of a unique 37-amino acid sequence, which associates with actin, and a Src homology 3 domain at the carboxyl terminus.

特異性

The antibody detects the 80-85 kDa protein of cortactin.

免疫原

Phosphorylated cortactin (Tyr466) synthetic peptide corresponding to mouse amino acid residues around tyrosine 466 (tyrosine 470 in the human sequence).

應用

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

This Anti-Cortactin Antibody, phospho-specific [Tyr466] is validated for use in WB for the detection of Cortactin.

外觀

Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation and preadsorbed with phosphopeptides to cortactin tyrosine 421 and 482 to remove cross-reactivity then affinity purified using phosphorylated cortactin (Tyr466) peptide. Antibody is supplied in phosphate-buffered saline (no Ca²⁺, no Mg²⁺), pH 7.3, containing 1 mg/ml BSA, and 0.05% sodium azide.

儲存和穩定性

Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2