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AB1254

Sigma-Aldrich

抗细胞色素P450酶CYP3A4抗体

serum, Chemicon®

同義詞:

Anti-Anti-CP33, Anti-Anti-CP34, Anti-Anti-CYP3A, Anti-Anti-CYP3A3, Anti-Anti-CYPIIIA3, Anti-Anti-CYPIIIA4, Anti-Anti-HLP, Anti-Anti-NF-25, Anti-Anti-P450C3, Anti-Anti-P450PCN1, Anti-Anti-VDDR3

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

human, pig

物種活性(以同源性預測)

mammals, rat

製造商/商標名

Chemicon®

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... CYP3A4(1576)

特異性

兔多克隆血清检测人和大鼠体内CYP3A4;通过所用免疫原的序列同源性,可以预期与CYP3A7、3A6V4;3A2V1、3A8、3A9的交叉反应性,但此时尚未测试。

免疫原

含有来自人CYP3A4的TVSGA的C端序列的合成肽。该肽与KLH偶联。

應用

抗细胞色素P450酶CYP3A4抗体可检测细胞色素P450酶CYP3A4水平 & 已出版 & 经过验证可用于IH & WB。
研究子类别
酶&生物化学
研究类别
代谢
蛋白质印迹: 1:1000-1:2000:使用微粒体膜级分,检测~54 kDa的条带;也可能存在其他条带。 抗体已成功用于LICOR荧光westerns检测CYP3A4。

免疫组化:10%福尔马林固定,石蜡包埋的组织1:200-1:400,建议使用微波-柠檬酸抗原回收。

最佳工作稀释度必须由最终用户确定。

標靶描述

57 kDa

外觀

兔抗血清。 不含防腐剂的液体。
未纯化

儲存和穩定性

自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品,在融化后和取下盖子之前,将原始小瓶进行离心。

分析報告

对照
肝组织

其他說明

浓度:请参考批次特异性浓缩物的检验报告。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Nicolas Quesnot et al.
Archives of toxicology, 92(10), 3077-3091 (2018-08-29)
CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived glucuronide appears
Konstantin Neukirch et al.
Journal of medicinal chemistry, 64(15), 11496-11526 (2021-07-20)
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (27a), which allosterically inhibits 5-LOX, being
Els Van Peer et al.
Basic & clinical pharmacology & toxicology, 114(5), 387-394 (2013-11-15)
Despite the increasing use of the minipig as a non-rodent species in general and juvenile toxicity studies, knowledge on their biotransformation processes and their ontogeny is scarce. Such data are prerequisite for the correct interpretation of non-clinical studies in this
Ulrik Kræmer Sundekilde et al.
Toxicology, 469, 153121-153121 (2022-02-11)
The circadian rhythm has profound effect on the body, exerting effects on diverse events like sleep-wake patterns, eating behavior and hepatic detoxification. The cytochrome p450 s (Cyps) is the main group of enzymes responsible for detoxification. However, the underlying mechanisms
Manuel Vlach et al.
Cells, 11(23) (2022-12-12)
The goal of this study was to establish a procedure for gene delivery mediated by cationic liposomes in quiescent differentiated HepaRG™ human hepatoma cells. We first identified several cationic lipids promoting efficient gene transfer with low toxicity in actively dividing

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