648469-M

Troglitazone

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).

• 同義詞: Troglitazone
• 經驗公式（希爾表示法）: C₂₄H₂₇NO₅S
• CAS號碼: 97322-87-7
• 分子量：: 441.54
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to yellow
• 溶解度: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 儲存溫度: −20°C
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
• InChI 密鑰: GXPHKUHSUJUWKP-UHFFFAOYSA-N

描述

一般說明

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21^Cip1 turnover by inhibiting PKC_δ signaling in VSMCs. Exerts positive inotropic effect via Ca²⁺ sensitization in the sarcoplasmic reticulum and inhibits Na⁺/H⁺ exchange activity and proliferation of macrovascular endothelial cells.

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMCs) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21^cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca²⁺ sensitization in sarcoplasmic reticulum and inhibits Na⁺/H⁺ change activity.

生化／生理作用

Primary Target
Peroxisome proliferator-activated receptors γ (PPARγ)

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.

其他說明

Masamune, A., et al. 2002. J. Biol. Chem.277, 141.
Boyault, S., et al. 2001. FEBS Lett.501, 24.
de Dios, S.T., et al. 2001. J. Diabetes Complications15, 120.
Furuse, Y., et al. 2001. Br. J. Pharmacol.133, 1307.
Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab.86, 1306.
Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol.38, 909.
Koga, H., et al. 2001. Hepatology33, 1087.
Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem.276, 37731.
Subbaramaiah, K., et al. 2001. J. Biol. Chem.276, 12440.
Takashima, T., et al. 2001. Int. J. Oncol.19, 465.
Takeda, K., et al. 2001. J. Biol. Chem.276, 48950.
Tanaka, T., et al. 2001. Cancer Res.61, 2424.
Wakino, S., et al. 2001. J. Biol. Chem.276, 47650.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable