625625

Trehalose, Dihydrate

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

• 同義詞: Trehalose, Dihydrate, 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
• 經驗公式（希爾表示法）: C₁₂H₂₂O₁₁ · 2H₂O
• CAS號碼: 6138-23-4
• 分子量：: 378.33
• MDL號碼: MFCD00071594
• 分類程式碼代碼: 12352201
• NACRES: NA.79

屬性

• 品質等級: 100
• 化驗: ≥97.5% (by Assay)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: water: 100 mg/mL
• 正離子痕跡: Fe: <5 ppm; heavy metals: <10 ppm
• 運輸包裝: ambient
• 儲存溫度: 15-25°C
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• InChI 密鑰: DPVHGFAJLZWDOC-PVXXTIHASA-N

描述

一般說明

Non-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.

警告

Toxicity: Standard Handling (A)

其他說明

Sarkar, S., et al. 2007. J. Biol. Chem. In press.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable