616458

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem, 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
• 經驗公式（希爾表示法）: C₂₁H₂₁NO₄
• CAS號碼: 666729-57-3
• 分子量：: 351.40
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 10 mg/mL; ethanol: 2 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC₅₀ = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC₅₀ = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC₅₀ = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Shimizu, T., et al. 2008. J. Med. Chem.51, 3326.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10-13 - German Storage Class 10 to 13