推薦產品
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
pale yellow
溶解度
DMSO: 10 mg/mL
ethanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI 密鑰
ZRRGOUHITGRLBA-UHFFFAOYSA-N
一般說明
一种细胞渗透性乙烯基砜化合物，通过靶向STAT3-SH2结构域并阻止其与上游激酶结合，作为STAT3细胞功能的抑制剂。Stattic对STAT家族成员的影响取决于温度，在37°C时似乎具有高度的STAT3选择性。显示抑制STAT3在Tyr705位的细胞磷酸化，对Tyr701处的STAT1磷酸化（在HepG2细胞中）或JAK1、JAK2和c-Src的磷酸化（在MDA-MB-231和MDA-MB-235S细胞中）几乎没有影响。
生化／生理作用
主靶
STAT3
STAT3
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
包裝
用惰性气体包装
警告
毒性：刺激性（B）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多1个月。注意：强烈建议使用新开的DMSO；DMSO中存在的硫醇杂质将修饰分子。强烈建议在每次使用前复溶。
其他說明
Schust, J., et al. 2006.Chem. Biol.13, 1235.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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