565777

γ-Secretase Inhibitor XVI

The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 同義詞: γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
• 經驗公式（希爾表示法）: C₂₀H₂₀F₂N₂O₄
• CAS號碼: 208255-51-0
• 分子量：: 390.38
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 效力: 10 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 2 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
• InChI 密鑰: XAPDRNSTUYCSQC-SGTLLEGYSA-N

描述

一般說明

A cell-permeable γ-secretase inhibitor (IC₅₀ Aβ = ~10 nM in 7PA2 cells) with anti-aggregation properties. Prevents early Aβ oligomerization by selectively blocking the Aβ dimer and trimer formation.

A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC₅₀ ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.

生化／生理作用

Cell permeable: yes

Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他說明

Walsh, D.M., et al. 2002. Nature 416, 535.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable