5.08505

A-803467

• 同義詞: A-803467, Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
• 經驗公式（希爾表示法）: C₁₉H₁₆ClNO₄
• CAS號碼: 944261-79-4
• 分子量：: 357.79
• MDL號碼: MFCD10574689
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 8 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mM; ethanol: 25 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChI 密鑰: VHKBTPQDHDSBSP-UHFFFAOYSA-N

描述

一般說明

A voltage gated sodium channel type 1.8 (Na_v1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC₅₀) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Na_v1.8 (IC₅₀ = 8 nM) and was >100-fold selective vs. human Na_v1.2, Na_v1.3, Na_v1.5, and Na_v1.7 (IC₅₀ values ≥ 1 µM).

生化／生理作用

Primary Target
Na_v1.8

警告

Toxicity: Standard Handling (A)

其他說明

Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable