5.06239

Bupropion Hydrochloride

• 同義詞: Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
• 經驗公式（希爾表示法）: C₁₃H₁₈ClNO · xHCl
• CAS號碼: 31677-93-7
• 分子量：: 239.74 (free base basis)
• MDL號碼: MFCD00055209
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 1.4 μM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: soluble
• 儲存溫度: 2-8°C
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• InChI 密鑰: HEYVINCGKDONRU-UHFFFAOYSA-N

描述

一般說明

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀ = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

生化／生理作用

Primary Target
DAT/NET

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable