5.05413

5-Iodo-A-85380 dihydrochloride hydrate

• 同義詞: 5-Iodo-A-85380 dihydrochloride hydrate, 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
• 經驗公式（希爾表示法）: C₉H₁₁IN₂O · 2HCl · xH₂O
• CAS號碼: 213550-82-4
• 分子量：: 363.02 (anhydrous basis)
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: water: 22 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1
• InChI 密鑰: RKVRGRXOYDTUEY-QMMMGPOBSA-N

描述

一般說明

A very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (K_i= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.

生化／生理作用

Primary Target
α4β2 nAChR

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Liu, X., et al., 2013. Psychopharm.In press.

Kennett, A., et al., 2012. Nicotine Tob. Res.14, 1339.

Huang. LZ, et al., 2011. Neuropharm.60, 861.
Mogg. AJ, et al., 2004. Neuropharm.60, 861.

Mukhin, A.G., et al., 2000. Mol. Pharmacol.47, 848.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable