5.04519

CIQ

• 同義詞: CIQ, (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
• 經驗公式（希爾表示法）: C₂₆H₂₆ClNO₅
• CAS號碼: 486427-17-2
• 分子量：: 467.94
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 10 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
• InChI 密鑰: VYMILMYEENZHAR-UHFFFAOYSA-N

描述

一般說明

A positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC₅₀ = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.

生化／生理作用

Primary Target
NMDA receptors

警告

Toxicity: Standard Handling (A)

準備報告

Slight warming is required for complete solubilization.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Mullasseril, P., et al. 2010. Nat. Commun.1, 1038.
Ogden, K., et al. 2013. Mol. Pharmacol.83, 1045.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable