5.04345

BX471

• 同義詞: BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
• 經驗公式（希爾表示法）: C₂₁H₂₄ClFN₄O₃
• CAS號碼: 217645-70-0
• 分子量：: 434.89
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: powder
• 效力: 1-5 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to beige
• 溶解度: DMSO: ≥25 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
• InChI 密鑰: XQYASZNUFDVMFH-CQSZACIVSA-N

描述

一般說明

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (K_i = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

生化／生理作用

Primary Target
CCR1

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°C）: Not applicable